Human iPS Cells

iPS cells (induced pluripotent stem cells) are a type of pluripotent stem cells that can be generated and reprogrammed from adult cells, like blood cells PBMC and epithelial cells in urine. iPSCs are nearly identical to ESCs genetically and functionally, yet are not considered ethically controversial. They can proliferate indefinitely in vitro and also can be differentiated into specific cell types. This technology provides hope for translational and regenerative medicine.

Application: Regenerative medicine, Disease modeling, Gene and cellular therapy, drug screening.

Human iPS Cell-Derived Mesenchymal Stem Cells

Mesenchymal stem cell sources are very limited. Mesenchymal stem cells (MSC) accounted for 0.001% ~ 0.01% of the total number of single nuclear cells in the bone marrow, and decreased with age. Mesenchymal stem cells are multipotent stromal cells, which can be differentiated into fat, bone, cartilage, muscle, liver, heart muscle, endothelium and other tissue cells in vitro under specific induction conditions. They maintain their multipotency after repetitive passage and free thaw cycles, therefore becoming an ideal source for tissue repairment and regenerative medicine.

Application: myocardial disease, liver disease, degenerative arthritis, articular cartilage injury.

Human iPS Cell-Derived Hematopoetic Stem Cells

Hematopoietic stem cells (HSC) are the progenitor cells of blood cells, including red and white blood cells. They are commonly used for transplantation as a treatment of leukemia, lymphoma, multiple myeloma, aplastic anemia, abnormal bone marrow proliferation syndrome and other diseases of the blood system, along with tissue repair and regeneration.

Application: acute lymphoblastic leukemia, degenerative neurotrophy.

Human iPS Cell-Derived Cardiomyocytes

Cardiomyocytes are distributed on the heart wall and in the large vessels around the heart, which controls the systole and diastole of the heart, and cardiac rhythm. Loss of cardiomyocytes is the main pathological feature in most of the heart and cardiovascular diseases. Heart muscles can regenerate themselves only in very limited instances. Therefore iPS cell-derived cardiomyocytes can provide an alternative approach in treating myocardial diseases.

Application: heart failure, arrhythmia, scar cardiomyopathy, myocardialinfarction.

Human iPS Cell-Derived Hepatocytes

Hepatocytes are cells of the main parenchymal tissue of the liver, which makes up to 85% of the liver's mass. These cells are involved in detoxification, protein synthesis, protein storage, carbohydrates and lipid metabolism,synthesis of cholesterol bile salts and phospholipids.

Application: liver fibrosis, cirrhosis, hepatitis.

Human iPS Cell-Derived Pancreatic β-Cells

The main function of insulin secretory cells (islet beta cells) is to secrete insulin. Insulin lowers blood sugar, and the lack of islet beta cells can lead to diabetes. Juvenile islet beta cells can proliferate, while the proliferation of adult isletsi beta cells is very limited. iPSC induced islet beta cells can be a source of transplantation to produce insulin-producing cells and thereby controling the level of blood glucose.

Application: Type I Diabete, Pancreatic partial resection.

Human iPS Cell-Derived Cortical Neural Stem Cells

Neual stem cells(NSC) are self-renewal and multipotent which can generate the neurons and glia cells of the nervous system. Not many NSCs persist in adult humans. NSCs were reported used in the repair of nerve injuries. Cell death is a characteristic of acute CNS disorder, and other neurodegenrative diseases. The loss of neurons can be circumvented to use cell replacement therapy via regenerative NCS, or iPS cell-derived NCS.

Application: cerebral palsy, neurodegenerative disease, craniocerebralinjury.